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EEG, ECoG, and EMG

A Matchless System, Scalable from 32 to 1024 Channels

Overview

Researchers worldwide use this robust system to record an almost endless variety of biopotentials including EEG, ECoG, and EMG. With TDT, your signal processing capabilities enable real-time power band analysis for BMI or direct export to Open Source BMI software. The optically isolated PZ5 NeuroDigitizer amplifier features fully differential amplification and onboard impedance measurement. Additional real-time control includes common reference averaging for signal denoising and wave rectified EMG signals to calculate contraction force.

Achieve synchronized stimulus generalization using onboard analog output or by adding high-quality stimulation modules. Data delay will never be a concern again – your system can continuously collect data 24/7, all in real-time. TDT’s Synapse software provides experimental control in a user-friendly design interface.

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Published research: EEG/ECoG/EMG

The newest papers in EEG/ECoG/EMG that used TDT systems.

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Advanced Science · 2026

Printing-Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, … Ivan R. Minev

The limitations of electrical neuromodulation are driving the development of neuroprosthetic systems enhanced with complementary modalities. A key technological challenge however remains the integration of the necessary hardware components (optical, thermal, fluidic, electrical) into miniaturized implants. Here we present a design framework, inspired by fast prototyping, that promises to reduce the complexity, fabrication time, and device bulk of multimodal neural interface systems. By combining extrusion‐based 3D printing of silicones and discrete electronic components, we integrated thermal neuromodulation and electrical recording capabilities in soft packages suitable for placement on the cortical surface of rodents. When linked to an autonomous auxiliary driver unit, these packages establish rapid, stable and localized hypothermia together with ElectroCorticoGraphy (ECoG) recording. In a rodent model of epilepsy (4‐aminopyridine), we demonstrate hypothermia‐induced suppression of seizure‐like activity. Our approach may advance the clinical translation of focal hypothermia as an alternative therapy for drug‐resistant focal epilepsies.

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Frontiers in Pharmacology · 2026

Blarcamesine improves EEG biomarkers of cortical dysfunction in a mouse model of fragile X syndrome

Carrie R. Jonak, Samantha A. Assad, Devin K. Binder, … Walter E. Kaufmann

Background Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism spectrum disorder. Previous studies in the Fmr1 knockout (KO) mouse model of FXS and affected individuals have identified common electroencephalographic (EEG) abnormalities, which constitute biomarkers of cortical dysfunction for drug treatments. Methods We evaluated the effects of three different doses of oral blarcamesine, a Sigma-1 receptor agonist (S1R), on FXS-relevant EEG biomarkers in Fmr1 KO mice utilizing a multielectrode array (MEA) on resting-state power (from delta to gamma frequencies) and network synchronization (inter-trial phase coherence [ITPC]) using three auditory stimulation paradigms (chirp, auditory steady-state response [ASSR] at 40 Hz and at 80 Hz). Results Blarcamesine-treated Fmr1 KO mice showed dose-dependent modulation of EEG biomarkers across cortical regions. Resting-state EEG power was reduced across multiple frequency bands, including suppression of the FXS-distinctive elevation in the gamma band. Significant improvements in ITPC were observed in all cortical regions for chirp stimulation and 40 Hz ASSR, while modest improvements were seen for 80 Hz ASSR. Conclusion Altogether, these data demonstrate that blarcamesine modulates multiple EEG biomarkers of cortical dysfunction in Fmr1 KO mice. Given that these biomarkers are associated with fundamental neurophysiological mechanisms underlying cognitive and behavioral abnormalities, and are shared between FXS mouse models and affected individuals, these findings are consistent with previously characterized S1R-mediated pharmacological effects of blarcamesine. These data support further investigation of blarcamesine’s clinical potential in FXS and other neurodevelopmental disorders.

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bioRxiv · 2026

Altered stimulus-specific adaptation at the auditory cortex of a mouse model of Fragile X Syndrome

Abdullah Abdullah, Xiuping Liu, Jun Yan, Ning Cheng

Auditory hypersensitivity or decreased sound tolerance is a common phenotype of Fragile X Syndrome (FXS). Impairments in adaptation, defined as the reduction in the neuronal responsiveness to repeating sounds, can contribute to this prevalent phenotype. Previous studies on event-related potential observed impairments in mismatch negativity (MMN) in both FXS individuals and in the FMR1 -knockout (KO) mouse model of FXS. Therefore, in the present study we characterized stimulus-specific adaptation (SSA), a neural correlate of MMN, at the auditory cortex (AC) of anesthetized (with ketamine/xylazine) female and male postnatal day 20 (P20) wild-type (WT) and FMR1 -KO mice, using the oddball paradigm with either 4 Hz or 1 Hz repetition rate. We observed robust SSA at the 4 Hz repetition rate of the oddball paradigm in the AC neurons of all four groups of animals. We also noted that the strength of SSA diminished between 4 to 1 Hz repetition rate. In addition, at both the 4 Hz and 1 Hz repetition rate, reduced SSA was observed particularly in the male FMR1 -KO mice compared to their WT counterparts, while female WT and FMR1 -KO mice displayed similar SSA. In terms of sex differences, male FMR1 -KO mice had lower SSA than female FMR1 -KO mice, while SSA was similar in male and female WT mice. Overall, our observation of reduced SSA in the male FMR1 -KO mice suggests that impairments in neuronal adaptation potentially contribute to the auditory hypersensitivity phenotype particularly within the male population.

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A Single System with Endless Applications:

  • Digitize waveforms at sampling rates up to ~ 50 kHz
  • Transmit waveforms to a DSP base station over a noiseless fiber optic link
  • Synchronized stimulus generation and data acquisition
  • Grow and evolve your experiments – DSP based systems provide complete flexibility, eliminating the limitations of other software

RZ2 Bioamp Processor

EEG, ECoG, and EMG Recording Control and Experimental Design with Synapse Software

See the difference for neurophysiology experiment design, data collection, and project management.

  • Timestamped waveforms, stimulus parameters, and external events stored into a single data set
  • Easy to configure multi-channel plots
  • Built-in access to RPvdsEx for custom processing

Synapse Software