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Optogenetics + Behavioral Neuroscience

CLOSED-LOOP STIMULATION WITH TDT’S REAL-TIME PROCESSOR

Description

Publications

The RZ10X processor is an all-in-one solution for behavioral neuroscience. Easily combine optogenetic stimulation and electrophysiology with precise closed-loop control. Stimulate with integrated LUX LEDs or trigger external light sources while simultaneously recording in real-time.

TDT’s Synapse software simplifies the design of a closed-loop system. For example, trigger optogenetic stimulation in response to:

  • detected seizure events
  • increased gamma or theta oscillation
  • changing firing patterns of a neuron
  • and more!

Michoud … Lacour, et al “Optical cuff for optogenetic control of the peripheral nervous system.” J Neural Eng. Feb, 2018. doi: 10.1088/1741-2552/aa9126.

Yazdan-Shahmorad … Sabes, et al “A Large-Scale Interface for Optogenetic Stimulation and Recording in Nonhuman Primates.” Neuron. Mar, 2016. doi: 10.1016/j.neuron.2016.01.013.

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System Components

RZ10X Lux-I/O Processor

Lux FP Leds & Sensors

PZ5 Flexible Amplifiers

Synapse - Neurophysiology Suite

iCon - Behavorial Chassis

WS Neuro Workstations

ACO Motorized Commutators

ZIF-Clip® Analog Headstages

ZIF-Clip® Digital Headstages

ZIF-Clip® Based Electrodes

SYNCHRONIZE STIMULATION WITH TDT'S REAL-TIME PROCESSOR

The RZ10X has integrated LUX LEDs for optogenetic stimulation (LED driving current: 1 – 1000 mA). Precisely control all stimulation parameters in Synapse, such as the number of pulses, frequency, and amplitude.

Simultaneously record electrophysiology with the PZ5 amplifier while stimulating for online evoked responses.

Closed-Loop Experiments

SYNAPSE: OPTOGENETICS AND CLOSED-LOOP CONTROL

Digital outputs can be triggered by events from any biological signal. For example, simply configure Synapse to detect spiking events (PCA spike sorting) to control the output of the Pulse Generator Gizmo. Pulses generated by the PulseGen Gizmo can be used in turn to drive the cycling of an optogenetic laser, grab frames from a behavioral camera, or other such experiments where time synchronization is critical.

Synapse Suite Software

Pulse Generator Gizmo
Easily design square pulse trains with minimal programming to control LUX LEDs, analog, and/or digital outputs connected to light sources.
Neural Stream Processor

Visualize, filter and store multiple channels of ephys signals in real-time, including single units, LFPs, ECoGs, EEGs, EMGs, ECGs, and more.

 
PCA Spike Sorting

Perform real-time filtering, spike detection, and principal component analysis (PCA) based spike sorting algorithm to cluster neural activity.